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Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage

Received: 27 May 2022     Accepted: 13 June 2022     Published: 21 June 2022
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Abstract

Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.

Published in International Journal of Neurosurgery (Volume 6, Issue 1)
DOI 10.11648/j.ijn.20220601.16
Page(s) 28-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Third Ventricle, Glioblastoma Multiforme, Haemorrhagic, Acute Hydrocephalus, Cyst

References
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[3] Sarikafa, Y., Akcakaya, M. O., Sarikafa, S., Ozkaya, F., Akdemir, O., & Celik, S. E. 2015; 26 (3): 147-50. Intraventricular glioblastoma multiforme: Case report. https://doi.org/10.1016/j.neucir.2014.09.001. Neurocirugia (Astur).
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[5] Ribalta, T., & Fuller, G. N. 2003. Brain tumors: An overview of histopathologic classification. In H. R. Winn (Ed.), Youman’s neurological surgery (5th ed) (pp. 661–672). Saunders.
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    Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. (2022). Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. International Journal of Neurosurgery, 6(1), 28-31. https://doi.org/10.11648/j.ijn.20220601.16

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    ACS Style

    Mohamed Awad Mohamed Hassan; Emad Mohammad Abdelhamid Hassan; Tariq Ahmed Saeed; Ghalib Almesedin; Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int. J. Neurosurg. 2022, 6(1), 28-31. doi: 10.11648/j.ijn.20220601.16

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    AMA Style

    Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int J Neurosurg. 2022;6(1):28-31. doi: 10.11648/j.ijn.20220601.16

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  • @article{10.11648/j.ijn.20220601.16,
      author = {Mohamed Awad Mohamed Hassan and Emad Mohammad Abdelhamid Hassan and Tariq Ahmed Saeed and Ghalib Almesedin and Saggaf Alawi Assaggaf},
      title = {Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage},
      journal = {International Journal of Neurosurgery},
      volume = {6},
      number = {1},
      pages = {28-31},
      doi = {10.11648/j.ijn.20220601.16},
      url = {https://doi.org/10.11648/j.ijn.20220601.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220601.16},
      abstract = {Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage
    AU  - Mohamed Awad Mohamed Hassan
    AU  - Emad Mohammad Abdelhamid Hassan
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    N1  - https://doi.org/10.11648/j.ijn.20220601.16
    DO  - 10.11648/j.ijn.20220601.16
    T2  - International Journal of Neurosurgery
    JF  - International Journal of Neurosurgery
    JO  - International Journal of Neurosurgery
    SP  - 28
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2640-1959
    UR  - https://doi.org/10.11648/j.ijn.20220601.16
    AB  - Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Neurosurgery Department, King Khalid Hospital, Hail, Kingdom of Saudi Arabia

  • Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia

  • Neurosurerg, King Abdulaziz Airbase Militay Hospital, Kingdom of Saudi Arabia

  • Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia

  • Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia

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