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Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature

Received: 18 July 2022     Accepted: 4 August 2022     Published: 10 August 2022
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Abstract

Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.

Published in International Journal of Neurosurgery (Volume 6, Issue 2)
DOI 10.11648/j.ijn.20220602.12
Page(s) 38-43
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Metastasis, Brain, Ovary, Adenocarcinoma, Cancer

References
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[2] Pakneshan S, Safarpour D, Tavassoli F, Jabbari B. Brain metastasis from ovarian cancer: a systematic review. J Neurooncol. Aug 2014; 119 (1): 1-6.
[3] Pogge von Strandmann E, Reinartz S, Wager U, Müller R. Tumor–Host Cell Interactions in Ovarian Cancer: Pathways to Therapy Failure. Trends in Cancer. Feb 2017; 3 (2): 137-48.
[4] Thomakos N, Diakosavvas M, Machairiotis N, Fasoulakis Z, Zarogoulidis P, Rodolakis A. Rare Distant Metastatic Disease of Ovarian and Peritoneal Carcinomatosis: A Review of the Literature. Cancers (Basel). 24 Jul 2019; 11 (8): 1044.
[5] Marchetti C, Ferrandina G, Cormio G, Gambino A, Cecere S, Lorusso D, et al. Brain metastases in patients with EOC: Clinico-pathological and prognostic factors. A multicentric retrospective analysis from the MITO group (MITO 19). Gynecologic Oncology. Dec 2016; 143 (3): 532-8.
[6] Gardner AB, Charo LM, Mann AK, Kapp DS, Eskander RN, Chan JK. Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes. Clin Exp Metastasis. Feb 2020; 37 (1): 107-13.
[7] Gadducci A, Tana R, Teti G, Fanucchi A, Pasqualetti F, Cionini L, et al. Brain Recurrences in Patients with Ovarian Cancer: Report of 12 Cases and Review of the Literature. ANTICANCER RESEARCH. 2007; 7.
[8] Pectasides D, Pectasides M, Economopoulos T. Brain Metastases from Epithelial Ovarian Cancer: A Review of the Literature. The Oncologist. 1 Mar 2006; 11 (3): 252-60.
[9] Longo R, Platini C, Eid N, Elias-Matta C, Buda T, ’Nguyen D, et al. A late, solitary brain metastasis of epithelial ovarian carcinoma. BMC Cancer. déc 2014; 14 (1): 543.
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[12] Johnston H, McTyre ER, Cramer CK, Lesser GJ, Ruiz J, Bourland JD, et al. Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer. J Radiosurg SBRT. 2017; 5 (1): 55-61.
[13] Wohl A, Kimchi G, Korach J, Perri T, Zach L, Zibly Z, et al. Brain Metastases from Ovarian Carcinoma: An Evaluation of Prognostic Factors and Treatment. Neurol India. dDec 2019; 67 (6): 1431-6.
[14] Celejewska A, Tukiendorf A, Miszczyk L, Składowski K, Wydmański J, Trela-Janus K. Stereotactic radiotherapy in epithelial ovarian cancer brain metastases patients. J Ovarian Res. 15 août 2014; 7: 79.
[15] Cooper KG, Kitchener HC, Parkin DE. Cerebral Metastases from Epithelial Ovarian Carcinoma Treated with Carboplatin. Gynecologic Oncology. Nov 1994; 55 (2): 318-23.
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Cite This Article
  • APA Style

    Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. (2022). Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. International Journal of Neurosurgery, 6(2), 38-43. https://doi.org/10.11648/j.ijn.20220602.12

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    ACS Style

    Pawendtaoré Esdras Zongo; Tarik Chekrine; Asmaa El Kebir; Mouna Bourhafour; Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int. J. Neurosurg. 2022, 6(2), 38-43. doi: 10.11648/j.ijn.20220602.12

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    AMA Style

    Pawendtaoré Esdras Zongo, Tarik Chekrine, Asmaa El Kebir, Mouna Bourhafour, Zineb Bouchbika, et al. Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature. Int J Neurosurg. 2022;6(2):38-43. doi: 10.11648/j.ijn.20220602.12

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  • @article{10.11648/j.ijn.20220602.12,
      author = {Pawendtaoré Esdras Zongo and Tarik Chekrine and Asmaa El Kebir and Mouna Bourhafour and Zineb Bouchbika and Nadia Benchakroun and Hassan Jouhadi and Mehdi Karkouri and Abdelhakim Lakhdar and Abdelatif Benider and Souha Sahraoui and Nezha Tawfiq},
      title = {Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature},
      journal = {International Journal of Neurosurgery},
      volume = {6},
      number = {2},
      pages = {38-43},
      doi = {10.11648/j.ijn.20220602.12},
      url = {https://doi.org/10.11648/j.ijn.20220602.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220602.12},
      abstract = {Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Brain Metastasis of Ovarian Cancer: Report four Cases and Review the Literature
    AU  - Pawendtaoré Esdras Zongo
    AU  - Tarik Chekrine
    AU  - Asmaa El Kebir
    AU  - Mouna Bourhafour
    AU  - Zineb Bouchbika
    AU  - Nadia Benchakroun
    AU  - Hassan Jouhadi
    AU  - Mehdi Karkouri
    AU  - Abdelhakim Lakhdar
    AU  - Abdelatif Benider
    AU  - Souha Sahraoui
    AU  - Nezha Tawfiq
    Y1  - 2022/08/10
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijn.20220602.12
    DO  - 10.11648/j.ijn.20220602.12
    T2  - International Journal of Neurosurgery
    JF  - International Journal of Neurosurgery
    JO  - International Journal of Neurosurgery
    SP  - 38
    EP  - 43
    PB  - Science Publishing Group
    SN  - 2640-1959
    UR  - https://doi.org/10.11648/j.ijn.20220602.12
    AB  - Objective: The objective of this manuscript is to present different cases of brain metastasis of ovarian cancer. These cases were managed by a multimodal treatment. Materials and methods: To present the clinical characteristics, the imaging, the anatomopathological and immunohistochemical data, and the multimodal treatment (surgery, chemotherapy, in toto brain radiotherapy, and stereotactic radiotherapy) of brain metastases of ovarian cancers. Results: Patients aged 48, 49, 57, and 62 years followed since 2018 and 2019 for clear cell carcinoma of the ovary, high-grade serous adenocarcinoma diagnosed by anatomy pathology and immunohistochemistry examination. They were treated with Paclitaxel carboplatin chemotherapy with the clinical, biological, and radiological response (evaluated according to RECIST criteria); then total surgery. Fifteen, thirty-seven, and nine months after the totalization surgery, the patients presented a confirmed cerebral metastatic relapse. This cerebral relapse was treated by surgical removal of the metastases and by either total brain radiotherapy or stereotactic radiotherapy followed by chemotherapy. Post-radiotherapy chemotherapy was performed with anti-VEGF (bevacizumab) at 14, 29, 31, and 17 months after the radiotherapy sessions. Conclusion: Brain metastases from ovarian cancer are rare. Of late onset, the management requires a multimodal treatment, with chemotherapy, surgery, and radiotherapy either total brain or by stereotaxis.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Pathology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Pathology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Neurosurgery, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

  • Department of Radiation Oncology, University Hospital Center Ibn Rochd, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco

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